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adipose tissue inflammation in aging skin


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Frontiers | Adipose Tissue Distribution, Inflammation and ...- adipose tissue inflammation in aging skin ,2020-2-25 · Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic …An anti-inflammatory phenotype in visceral adipose tissue ...2019-8-19 · Visceral adipose tissue is an immunogenic tissue, which turns detrimental during obesity by activation of proinflammatory macrophages. During aging, chronic inflammation increases proportional to ...



Adipose tissue inflammation in aging - ScienceDirect

2018-5-1 · 1.3. Adipose tissue inflammation in aging and obesity. Adipose, or fat tissue, is the largest endocrine organ in humans and in other cases, can be the largest organ in an obese individual. Adipose tissue plays a pivotal role in age-related metabolic dysfunction and longevity ( Tchkonia et al., 2010, Palmer and Kirkland, 2016, Ahima, 2009 ).

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Role of adipose tissue in facial aging | CIA

2017-12-6 · Role of adipose tissue in facial aging Uwe Wollina,1 Reinhard Wetzker,2 Mohamed Badawy Abdel-Naser,3 Ilja L Kruglikov4 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden …

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Adipose Tissue and Cutaneous Inflammation | SpringerLink

2017-4-25 · Adipose tissue (AT) is a highly dynamic and interactive organ with both immune and endocrine roles. It plays a major role in inflammation through the production of a huge class of bioactive mediators termed adipokines. Since adipocytes, macrophages and other cell types resident in AT are a non neglectable source of these mediators, together ...

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Adipose tissue inflammation and VDR expression and ...

2018-4-26 · Adipose tissue inflammation and VDR ... population aging, lack of physical activity, obesity, low fruit and vegetable intake, ... 7-dehydrocholesterol to previtamin D 3 in the skin, a process that is mediated by sunlight [2]. Then, vitamin D 2/D 3 is converted to 25-hydroxyvitamin D (25(OH)D) by CYP2R1 in the liver, which is the main form of ...

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Adipose Tissue Senescence and Inflammation in Aging is ...

2018-12-26 · Adipose tissue is at the crossroad of longevity and age-associated diseases ().Not only adipose tissue distributions change with age, but inflammation is primed at the adipose tissue prior to other organs during aging and onset of obesity ().Moreover, interventions that delay or limit fat tissue turnover, redistribution, or dysfunction in experimental animals enhance life …

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Frontiers | Adipose Tissue Inflammation Induces …

2017-8-28 · Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging. Aging is the greatest risk factor for developing chronic diseases. Inflamm-aging, the age-related increase in low …

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An anti-inflammatory phenotype in visceral adipose tissue ...

2019-8-19 · Visceral adipose tissue is an immunogenic tissue, which turns detrimental during obesity by activation of proinflammatory macrophages. During aging, chronic inflammation increases proportional to ...

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Aging and adipose tissue: potential interventions for ...

2016-12-15 · Sterile inflammation, or the presence of inflammation in the absence of known, identifiable infection, is a common feature of aging and is certainly increased in aging adipose tissue. Adipose tissue is thought to be a major contributor to the chronic, low-grade inflammation seen in aging ( Tchkonia et al., 2010 , Wu et al., 2007 ).

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Adipose Tissue and Cutaneous Inflammation | SpringerLink

2017-4-25 · Adipose tissue (AT) is a highly dynamic and interactive organ with both immune and endocrine roles. It plays a major role in inflammation through the production of a huge class of bioactive mediators termed adipokines. Since adipocytes, macrophages and other cell types resident in AT are a non neglectable source of these mediators, together ...

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Adipose tissue inflammation and VDR expression and ...

2018-4-26 · Adipose tissue inflammation and VDR ... population aging, lack of physical activity, obesity, low fruit and vegetable intake, ... 7-dehydrocholesterol to previtamin D 3 in the skin, a process that is mediated by sunlight [2]. Then, vitamin D 2/D 3 is converted to 25-hydroxyvitamin D (25(OH)D) by CYP2R1 in the liver, which is the main form of ...

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Frontiers | Adipose Tissue Inflammation Induces …

2017-8-28 · Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging. Aging is the greatest risk factor for developing chronic diseases. Inflamm-aging, the age-related increase in low …

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Skin aging: are adipocytes the next target?

2016-7-18 · INTRODUCTION. Skin aging is a continuous process which can be caused by both internal and external factors [1, 2].It is thought that intrinsic (chronological) and extrinsic (photo-induced) aging are realized through different pathways and can even cause different visual alterations of the skin [3, 4].These pathways are generally viewed to be connected with …

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Ageing, adipose tissue, fatty acids and inflammation ...

2014-11-4 · A common feature of ageing is the alteration in tissue distribution and composition, with a shift in fat away from lower body and subcutaneous depots to visceral and ectopic sites. Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function. In skeletal muscle, increased ectopic adiposity is linked to insulin resistance through …

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Dermal White Adipose Tissue: A Newly Recognized Layer …

2019-3-14 · Dermal white adipose tissue is a unique layer of adipocytes within the reticular dermis of the skin. Recently, several nonmetabolic activities have been discovered for dWAT and its fibroblast precursors. These functions include antimicrobial defense and roles in hair cycling, wound healing, and thermogenesis. In this review, we discuss recent progress in …

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Gene expression changes with age in skin, adipose tissue ...

2013-7-26 · Age-related gene expression. Expression profiles were determined from 856 individuals aged between 39 and 85 years from skin, adipose tissue,and LCL samples using the Illumina Human HT-12 V3 Bead chip.All the volunteers were female twins(336 MZ and 520 DZ) recruited from the TwinsUK Adult twin registry [] aged 39 to 85 years old, with an average age …

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Aging Leukocytes and the Inflammatory …

2021-12-17 · Tissue-resident B cells are expanded between 2- and 10-fold in the white visceral AT (aged adipose B cells, also called AABs) in an inflammation-dependent manner and predominantly in female mice (3,46,47). B-cell accumulation is localized to inducible lymphoid clusters, termed fat-associated lymphoid clusters (FALCs).

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Role of adipose tissue in facial aging

2017-12-6 · Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles.

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Adipose Tissue: What Is It, Location, Function, and More ...

Adipose tissue is a specialized type of connective tissue that arises from the differentiation of mesenchymal stem cells into adipocytes during fetal development. Mesenchymal stem cells are pluripotent cells that can transform into various cell types, including fat cells, bone cells, cartilage cells, and muscle cells, among others.

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Adipose Tissue Senescence and Inflammation in Aging is ...

2018-12-26 · Adipose tissue is at the crossroad of longevity and age-associated diseases ().Not only adipose tissue distributions change with age, but inflammation is primed at the adipose tissue prior to other organs during aging and onset of obesity ().Moreover, interventions that delay or limit fat tissue turnover, redistribution, or dysfunction in experimental animals enhance life …

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Young eosinophils rejuvenate ageing adipose tissues ...

2020-7-6 · The adipose tissue harbours multiple immune-cell types whose populations are known to be altered in disease conditions. A new study by …

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Frontiers | Adipose Tissue Distribution, Inflammation and ...

2020-2-25 · Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic …

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Adipose tissue inflammation in aging - ScienceDirect

2018-5-1 · 1.3. Adipose tissue inflammation in aging and obesity. Adipose, or fat tissue, is the largest endocrine organ in humans and in other cases, can be the largest organ in an obese individual. Adipose tissue plays a pivotal role in age-related metabolic dysfunction and longevity ( Tchkonia et al., 2010, Palmer and Kirkland, 2016, Ahima, 2009 ).

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Ageing, adipose tissue, fatty acids and inflammation

2017-2-7 · redistribution to ectopic sites. Low grade systemic inflammation is commonly observed in ageing, and may drive the adipose tissue dysfunction, as proinflammatory cytokines are capable of inhibiting adipocyte differentiation. Beyond increased ectopic adiposity, the effect of impaired adipose tissue function is an

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Inhibition of p38mapk Reduces Adipose Tissue …

2020-5-26 · Treatment of aging adipose tissues of WT mice with a specific p38mapk inhibitor SB203580 reduces IL-6 secretion. Conclusions Arg-II promotes IL-6 production in aging adipose tissues through p38mapk. The results suggest that targeting Arg-II or inhibiting p38mapk could be beneficial in reducing age-associated adipose tissue inflammation.

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